Not in the winter.
The Spirit of LaSalle Cruise Line is a passenger ferry between Menominee, Michigan, and Sturgeon Bay, Wisconsin, but it only operates from mid-May to mid-October.
The only ferry from or to Wisconsin that operates in the winter is the USS Badger between Manitowoc, WI and Ludington, MI.
http://www.ssbadger.com/newhome.aspx The Lake Express between Muskegon and Milwaukee does not operate in the winter.
http://www.lake-express.com/schedule/index.aspx